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Cancer cells not only switch from OXPHOS to lactate-dependent energy-generating pathways, but also upregulate antioxidant-related genes [e.g., NF-E2-related factor 2 (Nrf2)] to overcome a wide range of oxidative stress [27]

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To determine how NAC affects plasma thiol/disulfide concentrations, we analyzed plasma samples from an SCD patient who received 150 mg/kg of NAC intravenously infused over 1 hr